Unit 5 sc435

Specifically, the invention relates to the use of haptoglobin genotyping in the prognosis of the development of vasospasm following SAH, and antioxidants such as glutathione peroxidase mimetics for treatment. Specifically, the invention is directed to the use of haptoglobin genotyping in the prognosis of the development of vasospasm resulting from SAH, and to antioxidant therapies therefor.

Unit 5 sc435

What is claimed is: A method of determining the potential of a subject having cardiovascular disorder in a diabetic subject to benefit from administration of a composition comprising vitamin E or its derivative, metabolite, or analog and their combination; and a statin, comprising the step of determining a haptoglobin phenotype of the subject, wherein a subject having a haptoglobin phenotype will benefit from administration of the composition.

A method of determining the potential of a subject having cardiovascular disorder to benefit from administration of a composition comprising vitamin E or its derivative, metabolite, or analog and their combination; and a statin, comprising the step of determining a haptoglobin phenotype of the subject, wherein a subject having a haptoglobin phenotype will benefit from administration of the composition.

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A method of determining the potential of a subject having cardiovascular disorder in a diabetic subject to benefit from administration of a composition comprising vitamin E or its derivative, metabolite, or analog and their combination; and a GPx mimetic or its isomer, functional derivative, synthetic analog, pharmaceutically acceptable salt or combination thereof, comprising the step of determining a haptoglobin phenotype of the subject, whereby a subject having a haptoglobin phenotype will benefit from administration of the composition.

A method of determining the potential of a subject having cardiovascular disorder to benefit from administration of a composition comprising vitamin E or its derivative, metabolite, or analog and their combination; and a GPx mimetic or its isomer, functional derivative, synthetic analog, pharmaceutically acceptable salt or combination thereof, comprising the step of determining a haptoglobin phenotype of the subject, whereby a subject having a haptoglobin phenotype will benefit from administration of the composition.

A method of determining the potential of a subject having cardiovascular disorder in a diabetic subject to benefit from administration of a composition comprising a statin and a GPx mimetic or its isomer, functional derivative, synthetic analog, pharmaceutically acceptable salt or combination thereof, comprising the step of determining a haptoglobin phenotype of the subject, whereby a subject having a haptoglobin phenotype will benefit from administration of the composition.

A method of determining the potential of a subject having cardiovascular disorder to benefit from administration of a composition comprising a statin and a GPx mimetic or its isomer, functional derivative, synthetic analog, pharmaceutically acceptable salt or combination thereof, comprising the step of determining a haptoglobin phenotype of the subject, whereby Unit 5 sc435 subject having a haptoglobin phenotype will benefit from administration of the composition.

A method of treating, inhibiting or suppressing a cardiovascular disorder or alleviating a symptom associated therewith in a diabetic subject, comprising the steps of: A method of treating, inhibiting or suppressing a cardiovascular disorder or alleviating a symptom associated therewith a cardiovascular disorder in a subject, comprising the steps of: A method of treating, inhibiting or suppressing a cardiovascular disorder or alleviating a symptom associated therewith a cardiovascular disorder in a diabetic subject, comprising the steps of: A method of maintaining glycemic control in a diabetic subject comprising the step of bringing a subject exhibiting the Hp genotype HbA1c level down below 7.

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The method of any one of claims whereby said step of determining said haptoglobin genotype is effected by a method selected from a signal amplification method, a direct detection method, detection of at least one sequence change, immunological method or a combination thereof.

The method of claim 15, whereby said signal amplification method amplifies a molecule selected from the group consisting of a DNA molecule and an RNA molecule. The method of claim 15, whereby said direct detection method is selected from the group consisting of a cycling probe reaction CPR and a branched DNA analysis.

The method of claim 15, whereby step of determining said haptoglobin genotype is effected by an immunological detection method. The method of any one of claim 1, 2, 5, 6, 7, 8, 11, 12, 13, or 14, wherein the statin is lovastatin, compactin, pravastatin, atorvastatin, itavastatin, rosuvastatin, rivastatin, fluvastatin, simvastatin, cerivastatin, or their combination.

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The method of any one of claimswherein the cardiovascular disorder is myocardial infarct, cardiovascular death, stroke, or a combination thereof. The method of any one of claims claim orwherein said GPx mimetic or its isomer, functional derivative, synthetic analog, pharmaceutically acceptable salt or combination thereof, is a selenoorganic compound.

The method of claim 25, whereby said selenorganic compound is a benzisoselen-azoline or -azine derivative represented by the following general formula: The composition of claim 25, wherein said selenorganic compound is represented by formula II: The method of any one of claimswhereby administering is via oral, intravenous, intraaorterial, intramuscular, subcutaneous, parenteral, transmucosal, transdermal, intracranial, or topical administration.

The method of any one of claimswhereby said composition is in the form of a pellet, a tablet, a capsule, a solution, a suspension, a dispersion, an emulsion, an elixir, a gel, an ointment, a cream, or a suppository.

The method of any one of claimswherein the biological sample is blood, plasma, blood cells, saliva, cells derived by mouth wash, urine tears, biopsies, semen or their combination. The method of any one of claimswhereby the comprising contacting the subject with one or more additional agent, which is not a statin, nor vitamin E.

The method of claim 32, whereby the one or more additional agent not a statin, nor vitamin E, is an aldosterone inhibitor, and angiotensin-converting anzyme, an antioxidant, an angiotensin receptor AT1 blockecr ARBan angiotensin II receptor antagonist, a calcium channel blocker, a diuretic, digitalis, a beta blocker, a GPx mimetic or its isomer, functional derivative, synthetic analog, pharmaceutically acceptable salt or combination thereof, a cholestyramine, a NSAID, or a combination thereof.

The method of any one of claimswhereby the comprising contacting the subject with one or more additional agent, which is not a GPx or its isomer, functional derivative, synthetic analog, pharmaceutically acceptable salt or combination thereof, nor vitamin E.

The method of claim 34, whereby the one or more additional agent not a GPx mimetic or its isomer, functional derivative, synthetic analog, pharmaceutically acceptable salt or combination thereof, nor vitamin E, is an aldosterone inhibitor, and angiotensin-converting anzyme, an antioxidant, an angiotensin receptor AT1 blockecr ARBan angiotensin II receptor antagonist, a calcium channel blocker, a diuretic, digitalis, a beta blocker, a cholestyramine, a NSAID, a statin or a combination thereof.

The method of any one of claimswhereby the comprising contacting the subject with one or more additional agent, which is not a GPx mimetic or its isomer, functional derivative, synthetic analog, pharmaceutically acceptable salt or combination thereof, nor a statin.

The method of claim 36, whereby the one or more additional agent not a GPx mimetic or its isomer, functional derivative, synthetic analog, pharmaceutically acceptable salt or combination thereof, nor a statin, is an aldosterone inhibitor, and angiotensin-converting anzyme, an antioxidant, an angiotensin receptor AT1 blockecr ARBan angiotensin II receptor antagonist, a calcium channel blocker, a diuretic, digitalis, a beta blocker, a vitamin E or its derivative, metabolite, or analog or their combination, a cholestyramine, a NSAID, a statin or a combination thereof.

The composition of claim 38 or 40, whereby the statin is lovastatin, compactin, pravastatin, atorvastatin, itavastatin, rosuvastatin, rivastatin, fluvastatin, simvastatin, cerivastatin, or their combination.

The composition of claimwhereby said GPx mimetic or its isomer, functional derivative, synthetic analog, pharmaceutically acceptable salt or combination thereof, is a selenoorganic compound.

The composition of claim 43, whereby said selenorganic compound is benzisoselen-azoline or -azine derivatives represented by the following general formula: The composition of claim 43, wherein said selenorganic compound is represented by formula II: The composition of any one of claimsfurther comprising a carrier, excipient, flow agent, processing aid, a diluent or a combination thereof.

The composition of claim 41, wherein said carrier, excipient, lubricant, flow aid, processing aid or diluent is a gum, a starch, a sugar, a cellulosic material, an acrylate, calcium carbonate, magnesium oxide, talc, lactose monohydrate, magnesium stearate, colloidal silicone dioxide or mixtures thereof.

The composition of any one of claimsfurther comprising a binder, a disintegrant, a buffer, a protease inhibitor, a surfactant, a solubilizing agent, a plasticizer, an emulsifier, a stabilizing agent, a viscosity increasing agent, a sweetner, a film forming agent, or any combination thereof.

The composition of any one of claimswherein said composition is in the form of a pellet, a tablet, a capsule, a solution, a suspension, a dispersion, an emulsion, an elixir, a gel, an ointment, a cream, or a suppository.

The composition of any one of claimswherein said composition is in a form suitable for oral, intravenous, intraaorterial, intramuscular, subcutaneous, parenteral, transmucosal, transdermal, or topical administration.Description: This 5 lug front drag disc brake kit includes Billet Aluminum 4 Piston Calipers, Billet Aluminum Mounting Brackets, Grade 8 Hardware, Billet Aluminum Hats, Bearings, Seals, Hawk Performance Brake More Details».

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Unit 5 sc435

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